Season1:LincolnBurrows(DominicPurcell)isaccusedofmurderingTerrenceSteadman(JeffPerry),thebrotheroftheVicePresidentoftheUnitedStates.Becauseofconvincingevidence,Lincolnissentencedtodeath.HeisincarceratedinFoxRiverStatePenitentiarywhereheawaitshisexecution.Lincoln'sbrother,brilliantstructuralengineerMichaelScofield(WentworthMiller),isconvincedofLincoln'sinnocenceandformulatesanescapeplan.InordertogainaccesstoFoxRiver,Michaelcommitsarmedrobberyintentionallyinordertoreceiveafiveyearsentence.Whileincarceratedhemustraceagainsttheclockandmakeimportantconnectionswithotherinmatesandstaff.Onestaffmemberinparticularistheprisondoctor,SaraTancredi(SarahWayneCallies).MichaelbefriendsherwhenhepretendstosufferfromType1diabetesinordertogaindailyaccesstotheprison'sinfirmary.Thebrothers'fighttowardofftheexecutionisaidedbytheirlifelongfriendVeronicaDonovan(RobinTunney),whobeginstoinvestigatetheconspiracythatputLincolninjail.However,theyarehinderedbycovertagents,membersofanorganizationknownasTheCompany.TheCompanywasresponsibleforframingLincoln,andtheydidsobecauseofLincoln'sfather,AldoBurrows,andhisformerconnectionstothecompany.Thebrothers,alongwithsixotherinmates,FernandoSucre(AmauryNolasco),Theodore"T-Bag"Bagwell(RobertKnepper),BenjaminMiles"C-Note"Franklin(RockmondDunbar),David"Tweener"Apolskis(LaneGarrison),JohnAbruzzi(PeterStormare),andCharles"Haywire"Patoshik(SilasWeirMitchell)whocometobeknownastheFoxRiverEightfinallyescapeintheseasonfinalebecauseofthehelpofDr.SaraTancrediwhohasbeenconvincedbyMichaeltoleavetheinfirmarydoorunlocked.Becauseofherinvolvement,Saraoverdosesonmorphine. 　　Season2:Itbeginseighthoursaftertheescape,focusingmainlyontheescapees.SeriescreatorPaulScheuringdescribesthesecondseasonas"TheFugitivetimeseight"andlikensittothe"secondhalfofTheGreatEscape".[3]Thefugitivessplitupandjourneytolocationsacrossthecountrywiththeauthoritiesclosebehindthemastheyeachpursuetheirindividualgoals.BradBellick(WadeWilliams)getsfiredfromtheprisonwhereheworkedasaguardinseason1andchasesaftertheinmateshimselffortherewardmoney.SeveraloftheescapeesreuniteinsearchofalargecacheofmoneyburiedlongagobyanotherprisonerwhoisrumoredtobeD.B.Cooper.T-Bagmanagestoescapewiththemoney,andthebrothersspendtherestoftheseasontrackinghimdown,bothforthemoneywhichtheyneedtoescapethecountry,andbecauseScofieldfeelsresponsibleforreleasingthemurderer. 　　FederalagentAlexanderMahone(WilliamFichtner)isassignedtotrackdownandcapturetheeightfugitives,butisrevealedtobeworkingforTheCompany;Thegroupwantsalleightmen-especiallyLincoln-dead.Severaloftheescapeesarekilledorrecaptured,butthebrothersmakeittoPanama.Duringthebrothers'flight,Sara'sfather,GovernorFrankTancredi,ismurderedbecausehediscoversthetruthbehindLincoln'sinnocence.Afterdiscoveringhimdead,Sarareturnstoherapartmentonlytohavetofleeforherlife.ShemeetsupwithMichaelontwodifferentoccasions,remainingwithhimasthebrotherstrytobringdownthecurrentPresident,aCompanymember.Toensurethebrothers'safety,Saraallowsherselftobearrestedandfacesatria