问题标题:
英语翻译Ofnote,methodsbasedontheapplicationofHelper—dependentAdenoviralVectors(HDAdVs)haveprovensuccessfulwitheditinglargegenomicregionspotentiallyallowingforthesingle-stepcorrectionbyhomologousrecombinationofgenesb
问题描述:
英语翻译
Ofnote,methodsbasedontheapplicationofHelper—dependentAdenoviralVectors(HDAdVs)haveprovensuccessfulwitheditinglargegenomicregionspotentiallyallowingforthesingle-stepcorrectionbyhomologousrecombinationofgenesbearingmultiplepointmutationsorevencertaindeletionsandduplications[5,14].
刘佳欣回答:
值得注意的是,借助辅助病毒依赖型腺病毒载体(HDAdVs)的方法已证明确有其效,(这些方法可)编辑大型基因组区域,这就可能允许通过有多位点突变、甚至某因缺失、重复的基因同源重组进行单级校正【5,14】.
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